Smart drugs now have their own five minutes, and they are popular, especially among people who work hard mentally. Off-label medications for ADHD are particularly popular in the United States , and Adderall reigns supreme among them .
What is Adderall?
As mentioned above, Adderall is an ADHD drug that is based on amphetamine salts . Yes, the association with a popular recreational stimulant is right because it is a very similar preparation, but in the form of tablets and of pharmaceutical quality. The difference is also that black market amphetamine is a racemate (a mixture of D- and L- enantiomers), while the composition of Aderall is (all 25%):
- amphetamine sulfate,
- dextroamphetamine sulfate,
- dextroamphetamine sucrose,
- amphetamine aspartate monohydrate .
After calculating the mass of pure L- and D-amphetamine, it turns out that compared to the usual racemic mixture of amphetamine, here dextroamphetamine slightly dominates, and as it is a more active isomer, the effect may be slightly stronger. Adderall, both therapeutically and as a smart drug, is used in doses several times lower than recreational doses of amphetamine.
The beginning of the Adderall brand dates back to 1996. The quick release version was the first, and the XR ( extended release ) version was released later.
How does Adderall work?
In people who are actually diagnosed with ADHD, which may be related to dopamine deficiency, low doses of amphetamines can have a paradoxical effect – they offer composure and better focus instead of arousal. In people without this disease, the action will be classic – an increase in energy and motivation to act, improved well-being, and even a slight euphoria, and of course much better concentration and clarity of thinking, which is the reason for considering this topic in the game on the nerves.
The mechanism of action is largely based on the activation of TAAR1 receptors ( trace amine-associated receptor ), which plays a significant role in regulating the metabolism of monoamines – noradrenaline, dopamine and serotonin. As a result, it increases the concentration of these monoamines in the synaptic clefts, which translates into more intense binding of postsynaptic receptors and enhancement of the activity characteristic of these neurotransmitters. Amphetamine gets inside the neurons presynaptics with the help of dopamine transporters (DAT), which by the way causes competitive inhibition of dopamine reuptake – amphetamine-occupied transporters draw dopamine back into the neuron with less involvement, which further increases its level in the synapse. Much more could be written about the effects of amphetamines, but for an article about Adderall, such a summary should suffice . In a small summary – Adderall increases the release of monoamines into the synapse and inhibits their reuptake.
Adderall 20 mg capsule in extended release version
Adderall side effects
Side effects are very likely and can be quite a lot. These include:
- sleep problems, insomnia
- irritability, anxiety
- acceleration of heart rate and increase in pressure
- intestinal discomfort, pollakiuria
- decrease in appetite and weight
- decrease in potency
- increased sweating and dry mouth
- headache and dizziness
- teeth grinding
Where to buy Adderall?
As you can easily guess, due to the presence of amphetamine in the composition and the status of the drug, Adderall is illegal in Poland (and probably everywhere in the world) and you cannot buy Adderall without a prescription and medical indications. However, if the doctor finds such indications, he may issue a prescription with which target import is possible. Of course, Adderall preparations are circulating on the black market, often sold in single tablets, but for obvious reasons we do not recommend using them. It is also worth mentioning that the prices of this preparation are cosmic.
Also very popular is the drug Vyvanse , which is also based on amphetamines ( Lisdexamfetamine ). In a similar category, however, with slightly less potency is methylphenidate . This is contained in preparations such as Ritalin , Concerta or Medikinet. Another drug from the group of smart drugs is modafinil , belonging to the group of eugeroics.